Can Routine Vaccines Reduce Dementia Risk as You Age? What Else Lowers Your Risk?

 Unlike most topics which are covered here, I was hesitant to discuss the subject of vaccines because they have become so controversial.  However, the October 2023 AARP Bulletin reported on an interesting study about the relationship between vaccines and dementia.  It may or may not affect your decision to stay up-to-date with your routine vaccinations, but it may help some people make a thoughtful decision.

The core discovery from Paul E Schulz, an M.D. and Professor of Neurology, as well as the Director of the Neurocognitive Disorders Center at the McGovern Medical School at the University of Texas Health Center in Houston, said "There is the potential fringe benefit of vaccination, which is reducing the risk of Alzheimer's."

Fascinating, to say the least!

Of course, this does not mean that everyone who gets vaccinated for the flu and other diseases will never get dementia.  It also does not mean that everyone who decides against being vaccinated will definitely develop dementia.  It only means that getting regular vaccinations for common illnesses like the flu, Covid and Shingles will improve your odds of avoiding dementia.  

Researchers have long observed that our behaviors during our adult lives play a significant part in determining whether or not we will have dementia in later years.  Getting our vaccines may be just one more factor we need to consider. 

What are the Facts About Vaccines and Dementia Risk?

Researchers such as Schulze from the University of Texas, as well as other researchers around the world, have made the following observations:

1.  People who get vaccinated for the flu and other infectious diseases are less likely to get dementia. They speculate that it might be because, when you get sick from the flu and other infections, we become more likely to get dementia. They aren't certain, but they have observed that there seems to be a relationship between vaccines and dementia which indicates that vaccines appear to offer a substantial protection to the brain.  

2.  When they compared two groups of 935,887 patients each, in the U.S,  researchers learned that those who had at least one flu vaccine over a four year period were 40% LESS likely to develop Alzheimer's, compared to people who were not vaccinated.  The more vaccinations the patients had received, the better off they were.  It does appear that vaccines are causing people to be protected against some types of dementia.

3.  The flu vaccine was not the only vaccination which seemed to protect against dementia. When elderly people received the Shingles vaccine in Wales, the group who were vaccinated had about a 20% lower dementia risk over a seven year period compared to those who were not vaccinated against Shingles.

4.  When Schulze and other researchers at the University of Texas studied the effects of a variety of vaccines, including those for shingles, pneumococcal pneumonia, and the Tdap vaccine for tetanus, diphtheria and pertussis (whooping cough), they discovered that those who were vaccinated against these diseases also had a lower rate of dementia. 

5.  Virologist Robert T. Schooley, an M.D. and infectious disease specialist at the University of California in San Diego, also noticed that people who have chronic inflammation from diseases such as HIV show signs of faster cognitive decline.  This indicates that diseases which seem unrelated to Alzheimer's may still play a factor in developing dementia.

6.  It seems that using vaccines to avoid a wide variety of diseases can play a significant role in avoiding dementia.   

What Else Can You Do to Reduce Your Dementia Risk?

Researchers at the University of California in Irvine, the Cleveland Clinic, as well as others, have also discovered additional ways to avoid or postpone dementia.  Sometimes they are called the Six Pillars of Brain Health. These include:

1.  Eat a healthy diet with a "plant-slant."  Good examples are the Mediterranean Diet and the MIND Diet.

2.  Get regular exercise, at least 150 minutes a week, to increase the blood flow to your brain.

3.   Exercise your brain with activities such as reading books and working puzzles in order to slow down cognitive decline.

4.   Get at least seven hours of sleep each night to help your brain "cleanse" itself and remove the toxins that build up during the day. 

5.   Have regular physical exams and follow your doctor's instructions in order to stay as healthy as possible.  In particular, you want to do whatever you can to avoid strokes, heart disease and similar problems which can have a devastating effect on your brain.  Since Covid-19 has been shown to increase your risk of a stroke or heart attack in the following months, getting the Covid-19 vaccine is another way in which vaccinations could have a protective effect on your brain and lower your dementia risk.

6.   Socialize, socialize, socialize.  We need human connections, stimulating conversations, and a sense of being a part of a community in order to keep our brains operating at their best. 

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Many people believe that having a sense of gratitude can also help keep your brain healthy.  Being grateful for what we have and for the people in our lives is a good attitude to have for healthy mental health, and when working to maintain positive relationships with friends and families.  

You may want to get yourself something like this engraved bracelet, available in steel, gold or rose gold finishes, as a reminder of the importance of gratitude in your life.  You can personalize it with a name or significant date on the back.

Look for it and a wide variety of other gifts and jewelry at my Etsy Store, DeborahDianGifts at:

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Train Your Working Memory to Improve Cognitive Function

UCI Memory Lab Brain Training Helped Me.

In the summer of 2018, I took a brain class from a local community college, which started me on a journey to protect my cognitive ability, to the extent possible.  I was in my late 60s at the time.  During that class, a guest speaker from the University of California - Irvine MIND Program asked us to sign up for their C2C registry, which stands for "Consent to Contact."  They use this registry to find people who are willing to participate in a variety of studies to help them test different programs which might improve the memory of people as they age. I was excited to join their program!  If you have a research university near you, you might be able to enroll in a similar opportunity.

APT Webstudy

The first program UCI directed me to try has been the APT Webstudy, which is available to anyone, anywhere for free over the internet.  You can try it, too.  Since 2019, I have logged on, as instructed, every three months and used their online program to test myself to see if there has been any changes in my working memory.  Working memory could also be thought of as your very short-term memory, or your ability to keep track of things going on right now.

The program consists of doing a self-report on my memory, and then playing four games on the screen to test myself.  The tests consist of looking at a series of playing cards and trying to remember whether I have seen that card earlier in the test.  

The APT Web Study takes me about 20 minutes every three months, which means the time commitment is minimal. So far, my scores have remained remarkably stable, going up and down by only a small amount over the past three years. That is ideal.  The program describes itself as an Alzheimer's Prevention Trial for people over the age of 50.  I don't know that it will prevent Alzheimer's Disease, but it will provide you important clues to watch and discuss with your doctor if your scores begin to change.  If you want to try it out and track your memory yourself, you can find the free program at:  

https://www.aptwebstudy.org/

I have found it very reassuring to be able to test myself every few months and confirm that my working memory continues to operate normally. However, this test does not seem to do anything to improve my memory, as far as I can tell.  It is possible, however, that it is slightly training my working memory, which is a benefit in itself.

Next I Tried tDCS Brain Stimulation

In May of 2022, I also agreed to participate in a more active type of brain training involving the use of tDCS electrical stimulation on my brain, while I simultaneously completed a series of memory activities under the supervision of researchers. This study took place at the UCI Working Memory and Plasticity Lab under the direction of Dr. Susanne Jaeggi, with the help of a number of research assistants.  According to their brochure, they "have developed an intervention on cognitive training and successful aging.  The aim of the intervention is to optimize opportunities for cognitive health and wellbeing in older adults."  Anything that could help me achieve more successful aging sounds like a good program to me!

Over the past decade the researchers at the UCI Memory lab have "developed computerized interventions to improve learning and memory in diverse populations ... focused on working memory."  

They have used their interventions to train several hundred children, young adults, and older adults (like me!).  They have also found that just a couple of weeks of training improved working memory for at least several months, with the hope that the benefits will last much longer.   According to their research "the more you train, the more you improve."  

What Happened During the tDCS Experiment?

The first session began with a series of sixteen words which I was shown briefly. Then I was asked to recall as many as possible.  Afterwards, I was hooked up to the tDCS device, with two electrodes strapped to my head.  The letters stand for Transcranial Direct Current Stimulation. It is described as "a non-invasive, painless brain stimulation treatment that uses direct electrical currents to stimulate specific parts of the brain. A constant, low intensity current is passed through two electrodes placed over the head which modulate neuronal activity."  It has been used for several years as a treatment for depression and now they are doing research to see if it can also improve working memory.  Early research indicates that it may be effective. The idea of trying it sounded exciting to me, and also a little scary.  

While wearing this equipment, I used an iPad to perform a number of memory tests, which were in addition to the word memory test which I had been given at the start of the session.  The computer tests consisted of being shown an object, animal, plant or number and then recalling whether it was the same as the item I had watched scroll by briefly on the computer screen one back, then two back, and eventually three back.  

In other words, I might be shown a lemon, then an orange, then an apple, then a lemon, then a pear, then an apple, and so on.  When I got to the second lemon, I had seen it before "three back," so I clicked on it.  I had to keep on my toes, because I had also seen the apple three back, and I had to click on it.  I confess that at times I got confused about when I had seen an object before. Was it two back, three back, or four back?  However, I plunged ahead and tried my best.

After the tDCS electrodes were removed about 30 minutes later, I was asked to recall the words that I had been asked to remember at the beginning of the session!

Following the brain activities, I was taken to another building where they performed an MRI to see how my brain looked on the first day of the training program.

That was the end of the first session.

For sessions two through six, which took place the following week, I did all the same things, except I did not repeat the MRI that week.  At the beginning of each session I was shown a group of 16 new words, and asked to repeat them from memory.  Then, I was asked to recall all the words I could from earlier in the week. By Friday, I was being asked to recall as many of the 80 words I had been asked to memorize as possible! 

After the word recall, I spent about an hour each day in the lab with the tDCS electrodes strapped to my head, while performing a variety of memory matching tests, striving to improve how far back I could remember the items each time.

The following week, I attended session seven, which was a repeat of session one, including the MRI.  The researchers plan to compare the two MRIs to see if my brain underwent any physical changes as the result of the training.  

During the second MRI, I was given a device with two buttons on it. I was shown a series of words and asked to punch either the "yes" or "no" button to confirm whether or not the word I was shown briefly on a screen was a word I had been asked to memorize during the preceding week. I did this while the MRI machine was making its loud, metallic sounds.  It was very challenging and I know I made a few mistakes during the session.

The UCI Memory Lab plans to do a follow-up set of memory tests, plus an additional MRI, in three months to see if my memory and my brain have maintained their training. I certainly hope I continue to benefit from this training. I have noticed that it seems slightly easier for me to remember names and events since my seven sessions at the memory lab. Is it real improvement or am I just imagining it?  It is hard to know for sure.

Meanwhile, I may try some memory games to continue exercising my brain, even though I will not have the tDCS machine to use while practicing the memory games.  One highly ranked workbook I found was the "Memory Activity Book:  100+ Brain Exercises to Supercharge Your Memory."  (Ad) It is certainly worth a try while I attempt to retain as much of my enhanced memory as possible.  Anyone could use this book, or a similar one, to train their own memory.  UCI emphasizes that we all must "use it or lose it" when it comes to keeping our brains active.

I was also surprised to learn that it is possible to purchase your own tDCS device and, in fact, you can look here at a: wide variety of tDCS devices in various price ranges (Ad) and see if one of them could help give your own memory a boost.  I do not know if one is any better than the others, so you may want to read the reviews and discuss it with your private physician.  

The tDCS device I used at UCI did not have any negative side effects on me. I did not experience pain or any type of sensation, either during or after the procedure. However, your experience could be different.  They did question me frequently about whether it gave me a headache, made my scalp itch, cause any rashes, and things like that.  My conclusion from their questions is that some people do have negative side effects.

Brain Classes and Personal Behavior 

In addition to the studies mentioned above, I have continued to take brain classes and attend programs held by various researchers from the University of California at Irvine.   Here are the basics of the personal behaviors you can adopt in order to protect your brain health and retain your memory as long as possible:

Cognitive Engagement or challenging yourself mentally is an important key to brain health.  This means learning new skills, reading books, playing a musical instrument and things like that.

Social Engagement or spending quality time with family and friends, including making new friends, is beneficial to cognition.  The best "brain game" you can play is to be deeply engaged in an interesting conversation with other people.

Diet and Nutrition, or specifically adhering to a "heart healthy" diet such as the Mediterranean diet, is linked to overall brain health and longevity.  One of the most highly recommended diets for brain health is called the "Mind Diet" (Ad) and it is worthwhile to pick up a copy of the cookbook so you can follow their diet plan more closely.  

Physical Activity, including any type of exercise, can produce "beneficial changes to brain structure and cognitive function.  This means that physical activity can actually change the structure of your brain, and it can be virtually any activity you enjoy ... walking, swimming, dancing, gardening, etc.

Sleep is crucial for brain health.  In fact, every session I had with the tDCS machine started with questions about how I slept the night before.  

If you want to age well and maintain a strong working memory and your cognitive ability well into your retirement years, you may want to to take brain classes in your area, participate in any brain training they offer, and adopt the personal behaviors recommended above.  These actions could make a huge difference in the quality of your life in the future. 

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Photo credit: UCI Memory Lab and Amazon book cover

Tips for a Sharper Brain and Better Memory

While most of us will not completely lose our memory to Alzheimer's Disease or another form of dementia, there may be times when nearly all of us feel as though our thinking is a bit fuzzy or we cannot remember as well as we used to.  At the same time, we are constantly amazed by some of our peers who seem to stay "sharp as a tack."  Is there anything the rest of us can do to have a sharper brain and clear memory?  According to a number of leading experts, the answer is "Yes."

The Connection Between Your Heart and Brain

Our brain is dependent on the nutrients which our heart sends its way.  According to Dr. Hannah Gardener in the Department of Neurology at the University of Miami, the stronger our heart, the less cognitive decline we will experience.  She suggests that everyone strives to meet as many of the goals on this list as possible:

Stop Smoking
Have a BMI of under 25
Be physically active at least 150 minutes a week
Have a total cholesterol under 200 mg/dL
Have a healthy blood pressure under 120/80 mmHg
Have a healthy blood sugar under 100 mg/dL
Eat a diet rich in fruits, veggies and whole gains; low in sodium and sweets

Even if you cannot achieve all of the above goals perfectly, the closer you come, the better off your brain will be.

Follow the MIND Diet

This blog has discussed the MIND diet before.  It is short for Mediterranean-DASH Intervention for Neurodegenerative Delay.  MIND is much easier to remember.  Below is a brief summary of the diet, although anyone who wants to follow it would be smart to get a more detailed book on the subject.

DO EAT

6 servings of salad a week
7 servings of other vegetables a week
2 servings of berries a week
5 servings of nuts a week
3 servings of whole grains a day
1 serving of fish (not fried) every week
3 servings of beans a week
2 servings of poultry a week
Use extra-virgin olive oil instead of butter
Optional: 1 glass of wine a day

LIMIT THESE FOODS

Butter - no more than one tablespoon a day
Cheese - no more than one serving a week
Red meat - no more than four servings a week
Fried foods - less than one serving a week
Sweets and pastries - no more than five servings a week

Exercise Your Brain

Research has shown that people who regularly give their bodies and brains a work-out are able to postpone the signs of cognitive decline.  Here are some of the things everyone should do:

Get exercise - walk, cycle, swim and lift light weights - 150 minutes a week
Play games - chess, board games, puzzles, etc.
Meditate - spend your "down time" meditating a few minutes every day
Explore Your Artistic Side - sing, act, draw, paint or play an instrument
Read - in particular, read books as well as newspapers or magazines

Other Health and Lifestyle Changes

In addition to the above recommendations, research has shown a link between socializing with others and having a higher level of cognition.  On the other hand, people who are lonely tend to have poorer brain health.  Stay in touch with family and friends.  Join a club.  If you are religious, get involved in a place of worship.  Sign up to take classes.  The more time you spend interacting with other people and learning new things, the more likely you will be able to postpone dementia.

In addition, see your doctor regularly and treat any other problems you may have, including emotional ones.  People who have depression in middle age are at a higher risk for cognitive decline in later life.  People who have sleep problems also see more rapid mental decline as they age.  Talk to your doctor about any health issues you are experiencing and get them treated.  

Medications and Dementia

If you believe that you or a loved one is experiencing signs of dementia, see your doctor as soon as possible.  Researchers are continually discovering new medications which seem to slow down the progression of Alzheimer's Disease and other forms of dementia.  The sooner these drugs are started, the more successful they are.

In addition, it is possible your brain fogginess or symptoms of dementia could actually be a side effect of a medication you are currently taking.  If you suspect this could be your situation, talk to your doctor about changes which could be made to your prescriptions to minimize this problem.


If you are interested in learning more about how to maintain your health as you age, financial planning, Medicare, Social Security, where to retire and more, use the tabs or pull down menu at the top of the page to find links to hundreds of additional helpful articles.

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