Saturday, February 8, 2020

GAIN Could Treat Alzheimers in Some Patients - How to be Part of the Study

Good news for those who are concerned about Alzheimer's Disease.  I recently learned about a trial for a new drug called GAIN which appears to have had some success in restoring memory and reducing signs of Alzheimer's Disease in certain patients. The drug is currently undergoing human trials, and researchers are looking for volunteers between the ages of 55 and 80 who have been diagnosed with mild to moderate Alzheimer's Disease.  Trial participants must also have a caregiver or family member who can attend study visits, report on how the subject seems to be handling daily living, and confirm that the patient is taking the medication.

It does not matter whether or not you are currently being treated with another medication in an effort to slow down the progression of your Alzheimer's Disease.  They will not ask you to stop any other medications you are currently using.  GAIN can be used alone or in addition to your current medications, not instead of them.  So far, the results of the study have been interesting and the researchers have been encouraged by what they have seen.   However, study samples have been small, so it is important that more people participate in the trial.

How Does GAIN Treat Alzheimer's Disease?

Readers of this blog will know that untreated gum disease in our mouth has been implicated in causing other health problems, included heart disease and an increased risk of dementia.  According to the website for GAIN, this drug trial, "is based on the growing body of scientific evidence that the bacteria P. gingivalis, commonly associated with gum disease, can infect the brain and cause Alzheimer’s disease." It is "an investigational drug designed to inactivate toxic proteins released by the bacteria and stop or slow further damage to healthy brain cells. A study in a small group of Alzheimer’s patients has shown promise in improving memory."

This is a revolutionary approach to treating Alzheimer's Disease.   While scientists have long suspected that toxic proteins in the brain contribute to Alzheimer's Disease, only recently have they discovered that some of those toxic proteins may be related to the gingivitis gum bacteria which also causes the loss of bone and teeth in the mouth, as well as other health problems.  In fact, they have learned that 90% of people who have been diagnosed with Alzheimer's Disease have evidence of P. gingivalis in their central nervous system.

Where to Get More Information about GAIN

The trial is being conducted at 90 locations around the United States and Europe, as well as in the United Kingdom.  The researchers hope to find at least 500 study participants.  You can get more information about the drug and find out how to participate in the trial at  You can also download the study brochure which goes into even more detail about the drug and how you can participate in the trial, if you think you may be interested.  The study is being sponsored by Cortexyme.

More Ways to Cut Risk of Alzheimer's and Other Forms of Dementia

While this research on the effects of mouth bacteria on our brain is groundbreaking, there are additional ways you can help reduce your risk of developing Alzheimer's Disease, dementia and other types of cognitive decline.  Diet, exercise, socialization and many other factors are also important.

You can develop your own personal plan to protect your brain by reading  "The Alzheimer's Solution."  (Ad)  It contains a great deal of helpful information, and I highly recommend it, since none of us want to lose our memories and our independence as we age.

More Conclusions from this Research

One obvious result of this research is the importance of caring for our gums and teeth if we want to live a long, healthy life, free from heart disease and dementia. While gingivitis is not the only cause of these health problems, it is one of the risk factors we can reduce or eliminate.

If you are interested in learning more about financial planning for retirement, where to retire, Social Security, Medicare, common medical issues as you age, and more, use the tabs or pull down menu at the top of the page to find links to hundreds of additional helpful articles.

Disclosure: This blog may contain affiliate links. If you decide to make a purchase from an Amazon ad, I'll make a small commission at no extra cost to you.

You are reading from the article:

Photo credit:  Pixabay

No comments:

Post a Comment

Thank you for leaving a comment. Your thoughts and insights about retirement are always appreciated. However, comments that include links to other sites will usually not be published.